Scientists Finally Solve a 50-Year Mystery Hidden in Solid Nitrogen

Researchers have uncovered compelling evidence about the elusive structure of a high-pressure phase of solid nitrogen.
The Lancet

First-line systemic treatment strategies in patients with initially unresectable colorectal cancer liver metastases (CAIRO5): an open-label, multicentre, randomised, controlled ...

aDepartment of Epidemiology, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands bDepartment of Surgery, University Medical ...
Frontiers

Methods to improve the accuracy of next-generation sequencing

Next-generation sequencing (NGS) is present in all fields of life science, which has greatly promoted the development of basic research while being gradually applied in clinical diagnosis. However, ...
Frontiers

Methanogen Community Dynamics and Methanogenic Function Response to Solid Waste Decomposition

The world is facing the challenges of energy shortage and climate change. Various innovation techniques are developing to produce and recover clean energy such as methane (Niu et al., 2014; Li et al., ...
Front Line Genomics

The evolution of DNA sequencing technologies

The order of nucleotides within a sequence of DNA is important. It underpins subsequent protein function and, in cases of mutations, the subsequent disease manifestation. Determining the order of ...
Europe PMC

Solid-phase enzyme catalysis of DNA end repair and 3' A-tailing reduces GC-bias in next-generation sequencing of human genomic DNA.

The use of next-generation sequencing (NGS) has been instrumental in advancing biological research and clinical diagnostics. To fully utilize the power of NGS, complete, uniform coverage of the entire ...
The Lancet

FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular ...

nUnit of Medical Oncology, Medical Centre Hospital Santa Croce and Carle, Cuneo, Italy oUnit of Medical Oncology, Hospital San Gerardo, Monza, Italy ...
C&EN

DNA-Encoded Solid-Phase Synthesis: Encoding Language Design and Complex Oligomer Library Synthesis

The promise of exploiting combinatorial synthesis for small molecule discovery remains unfulfilled due primarily to the “structure elucidation problem”: the back-end mass spectrometric analysis that ...
C&EN

Pyrosequencing Reveals the Key Microorganisms Involved in Sludge Alkaline Fermentation for Efficient Short-Chain Fatty Acids Production

This file contains Table S1 and Figures S1–S3. This material is available free of charge via the Internet at http://pubs.acs.org. Smart citations by scite.ai ...
Cancer Research

A Phase I Trial of Liposomal Doxorubicin, Bevacizumab, and Temsirolimus in Patients with Advanced Gynecologic and Breast Malignancies

Clin Cancer Res (2011) 17 (21): 6840–6846. Purpose: Liposomal doxorubicin (D) and bevacizumab (A) are active single agents in gynecologic and breast malignancies which share a resistance mechanism: ...
PNAS

Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire

Direct analysis of phage displayed paratope diversity was made possible by recent advances in long-read pyrosequencing, a novel application of profile HMM-based sequence analysis, and syntenic ...