The work presents a valuable extension of qFit-ligand, a computational method for modeling conformational heterogeneity of ligands in X-ray crystallography and cryo-EM density maps. The authors ...
Department of Chemistry, University of Wisconsin−Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States Department of Physics-Affiliate, University of Wisconsin−Madison, 1150 ...
Statins are effective cholesterol-lowering drugs. Lovastatin, one of the precursors of statins, is formed from dihydromonacolin L (DML), which is synthesized by lovastatin nonaketide synthase (LovB), ...
Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) in mammalian nitric oxide signaling. We determined structures of full-length Manduca sexta sGC in both inactive and active ...
School for Sustainable Engineering and the Built Environment, Arizona State University, Tempe, Arizona 85281, United States The Biodesign Institute Center for Environmental Health Engineering, Arizona ...
A simple geometric continuous model of self-organized criticality (SOC) is proposed. This model belongs to the field of tropical geometry and appears as a scaling limit of the classical sandpile model ...
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