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A new single-cell atlas shows how epigenetic changes reshape brain cells during aging, revealing genomic instability, ...

Mount Sinai researchers have published the first organ-wide human skin spatial atlas from across the body. It provides an ...

The integrated organ-on-chip platform offers 10--100x cost efficiency and 80% reduction in animal use, bridging the gap between preclinical NHP research and human clinical success. SUZHOU, China, SAN ...

A single-cell atlas of brain aging epigenetics has mapped methylation, chromatin, and gene activity changes across 36 cell ...

Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to ...

Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to Parkinson's to ALS and beyond, is expected to double every 20 years. Though ...

We introduce a novel deep learning framework, SpaGene, which integrates scRNA-seq data and spatial transcriptomics data through an encoder-decoder architecture with translators, and discriminators, ...

Prostate cancer: Correlating the clinical phenotype to the genotype. Association of a post-prostatectomy digital pathology–based multimodal artificial intelligence (MMAI) biomarker with nodal and ...

Use of ultra-sensitive whole genome circulating tumor DNA detection to predict early recurrence in high-risk localized RCC after nephrectomy: Preliminary real-world findings. Forty-two genes ...

Abstract: Spatial transcriptomics has revolutionized the ability to investigate transcriptional patterns within tissue morphology. However, many ST clustering pipelines operate on a single preselected ...