ahajournals.org

T-World Virtual Human Cardiomyocyte. I. Development, Validation, and Cell Arrhythmogenesis

Cardiovascular disease is the leading global cause of morbidity and mortality. New technologies are needed to improve mechanistic understanding and inform therapeutic strategies. Human-centric cardiac ...
GitHub

Rumor Spreading Complex Networks Simulations

ruscs provides tools for simulating how rumors spread. The package implements the Maki-Thompson model with support for quasi-stationary method and control strategies for the simulation.
IEEE

Deterministic, Stochastic, and Hybrid Approaches in Tumor Growth Modeling

Abstract: Mathematical modeling is an indispensable tool in computational oncology, providing a framework to analyze tumor growth and therapeutic response. Depending on the biological scale and ...
ahajournals.org

Epigenetic Modulation of Vascular Smooth Muscle Cell Phenotype Switching in Early-Onset Acute Myocardial Infarction

The epigenetic mechanisms underlying early-onset acute myocardial infarction (AMI) remain insufficiently characterized. The present study aims to elucidate the pathophysiology of early-onset AMI by ...
eLife

A differentiable Gillespie algorithm for simulating chemical kinetics, parameter estimation, and designing synthetic biological circuits

This important study introduces a fully differentiable variant of the Gillespie algorithm as an approximate stochastic simulation scheme for complex chemical reaction networks, allowing kinetic ...
Frontiers

Applying neural ordinary differential equations for analysis of hormone dynamics in Trier Social Stress Tests

Introduction: This study explores using Neural Ordinary Differential Equations (NODEs) to analyze hormone dynamics in the hypothalamicpituitary-adrenal (HPA) axis during Trier Social Stress Tests ...
ascopubs.org

Associations Between Radiation Oncologist Demographic Factors and Segmentation Similarity Benchmarks: Insights From a Crowd-Sourced Challenge Using Bayesian Estimation

The quality of radiotherapy auto-segmentation training data, primarily derived from clinician observers, is of utmost importance. However, the factors influencing the quality of clinician-derived ...
Hacker

67 Stories To Learn About Problem Solving

Lets geek out. The HackerNoon library is now ranked by reading time created. Start learning by what others read most. Lets geek out. The HackerNoon library is now ranked by reading time created. Start ...
The Lancet

Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesis

aMolecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland bOrganismal and Evolutionary Biology Research ...
PNAS

The limitations of machine learning models for predicting scientific replicability

An insufficient number of training samples can result in wide CIs and lead to inflated estimates of classification accuracy (Fig. 1A). Underpowered studies with insufficient sample sizes can inflate ...
Bleeping Computer

Massive ESXiArgs ransomware attack targets VMware ESXi servers worldwide

Article updated on 2/6/23 with additional information and updated statistics. Admins, hosting providers, and the French Computer Emergency Response Team (CERT-FR) warn that attackers actively target ...