Covalent inhibitors are a specialized class of small molecules designed to form chemical bonds with their target proteins, often resulting in prolonged target engagement and enhanced potency. The ...

Thousands of proteins are known to cause disease, but while the biological activity of these proteins is understood, the way to hit and modulate them with a drug is not. Nature still has ways to bind ...

Disulfide bonds play a pivotal role in the folding and stability of many bacterial proteins, influencing not only their tertiary structure but also their biological activity. In bacteria, the ...